NBA odds, lines, spreads, picks, predictions for Friday, May 15: 3-way parlay pays over +500

Friday night features two NBA Game 6 conference semifinal matchups. In the Eastern Conference, the Cavaliers are 3.5-point favorites vs. the Pistons at 7 p.m. ET. In the West, the Spurs are 4.5-point favorites over the Timberwolves at 9:30 p.m. ET. 

Before locking in any NBA bets or parlays, make sure you see what SportsLine's advanced computer model has to say. 

SportsLine's model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past eight-plus seasons. The model entered the second round of the 2026 NBA playoffs on a sizzling 26-9 roll (74%) on top-rated NBA spread picks this season. Anyone following could have seen HUGE returns!

The model has evaluated the Friday NBA odds and locked in three confident NBA best bets. If you successfully parlay them you'd be looking at a big payout of over +500.

One pick we'll give away: The model is backing the Over 210.5 in the Pistons vs. Cavaliers matchup.

The model has also locked in two more strong picks, including an over/under pick that hits in over 60% of simulations! You ABSOLUTELY need to see it right now.

So what are the NBA best bets for Friday? ... Join SportsLine now to see who wins and covers every single NBA game this week, all from the model that's on a 26-9 run on top-rated NBA picks!