Nationals vs. Pirates odds, line, prediction: 2026 MLB picks for Thursday afternoon from proven model

The Pittsburgh Pirates go for the series win when they take on the visiting Washington Nationals in the last of their four-game set on Thursday. Pittsburgh is coming off a 2-0 win over Washington on Wednesday. The Nationals (8-10), who have won four of their last six games, are 7-5 on the road this season. The Pirates (11-7), who have won four of their last six, are 6-3 on their home field.

First pitch from PNC Park in Pittsburgh is set for 12:35 p.m. ET. The Pirates lead the all-time series 345-320, but the teams have split their last 12 meetings. Pittsburgh is a -157 favorite on the money line (risk $157 to win $100) in the latest Nationals vs. Pirates odds, while the over/under, is 8.5. 

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The model has simulated Nationals vs. Pirates 10,000 times and the results are in. The model is going Over on the total, and is also says one side of the money line has ALL the value!

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