The Philadelphia Phillies will look to extend their winning streak to five games when they take on the Washington Nationals in the first of a three-game series on Friday night. The Nationals (52-75), who are fifth in the National League East, are 27-36 on the road this season. The Phillies (74-53), who are first in the NL East, are 40-21 on their home field in 2025.
First pitch from Citizens Bank Park in Philadelphia is set for 6:45 p.m. ET. The Phillies have won six of the past 10 meetings with the Nationals. Philadelphia is a -191 favorite on the money line (risk $191 to win $100) in the latest Nationals vs. Phillies odds from DraftKings Sportsbook, while the total number of runs Vegas thinks will be scored, or the over/under, is 9. in the latest MLB odds.
Before you make any Nationals vs. Phillies picks or MLB predictions, you need to see what the SportsLine Projection Model has to say.
The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 22 of the 2025 MLB season a profitable 33-24 on top-rated MLB money-line picks. It has excelled making home run prop picks this season, returning nearly 60 units of profit. Anybody following could have seen strong returns!
The model has simulated Nationals vs. Phillies 10,000 times and the results are in. We can tell you the model is going Over on the run total, and it also says one side of the money line has all the value!
Who wins Nationals vs. Phillies, and which side of the money line has all the value? ... Join SportsLine right now to find out which side of the money line you should be all over, all from the model on a 33-24 roll on top-rated MLB money-line picks!
GET VEGAS EXPERT PICKS FOR NFL, MLB, NBA, CBB, GOLF, NHL, HORSE RACING AND MORE - PLUS ADVANCED COMPUTER SIMULATIONS, WINNING TOOLS, AND MORE!
Written by Daniel Kohn
View expert profile
