MLB odds, lines, picks, predictions for Wednesday, Aug. 5: 3-way parlay pays over +800

A full 15-game Major League Baseball schedule is set for Wednesday, including an intriguing American League matchup between the Chicago White Sox and Boston Red Sox at Fenway Park in Boston at 7:10 p.m. ET. Other interesting matchups to consider within an MLB parlay include Marlins vs. Braves, Cardinals vs. Yankees, Pirates vs. Brewers, Tigers vs. Mariners and Padres vs. Diamondbacks.

Atlanta is the -126 favorite (risk $126 to win $100) over the Marlins per the latest MLB odds as these two National League East postseason contenders meet in the second of a three-game series. The Yankees (-149) are also favored versus the Cardinals, with the Brewers (-136) home favorites vs. Paul Skenes and the Pirates.

Before locking in any MLB bets or parlays, make sure you see what SportsLine's advanced computer model has to say. 

The SportsLine Projection Model simulates every MLB game 10,000 times and entered Week 20 of the MLB season on a sizzling 42-29 run on all top-rated MLB picks. It also excelled at making home run prop picks in 2025, returning nearly 30 units of profit. Anybody following could have seen strong returns!

The model has evaluated the Wednesday MLB odds and locked in three confident MLB best bets. If you successfully parlay them you'd be looking at a big payout of over +800.

One pick we'll give away: The model is backing the Over 7 in the Pirates vs. Brewers matchup, saying the Over hits well over 60% of the time. 

The model has also locked in two other plays, creating an MLB parlay which pays out over +800! You ABSOLUTELY need to see it right now.

So what are the MLB best bets for Wednesday? ... Join SportsLine now to see who wins every single MLB game, all from the model that's on a 42-29 run on top-rated MLB picks!

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