MLB odds, lines, picks, predictions for Monday, July 27: 3-way parlay pays nearly +500

Twelve games highlight Monday's Major League Baseball schedule, and features a key National League Central Division matchup between the Chicago Cubs and St. Louis Cardinals at 7:45 p.m. ET. Other intriguing matchups to consider within an MLB parlay include Mariners vs. Rangers, Orioles vs. Tigers, Diamondbacks vs. Pirates and Guardians vs. Reds.

The Cubs are the -120 favorite per the latest MLB odds as these two NL contenders open a four-game series. The Braves (-116) are also favored versus the New York Mets, with the Yankees (-149) road favorites vs. the Chicago White Sox.

Before locking in any MLB bets or parlays, make sure you see what SportsLine's advanced computer model has to say. 

The SportsLine Projection Model simulates every MLB game 10,000 times and entered Week 18 of the MLB season on a sizzling 35-21 run on all top-rated MLB picks. It also excelled at making home run prop picks in 2025, returning nearly 30 units of profit. Anybody following could have seen strong returns!

The model has evaluated the Monday MLB odds and locked in three confident MLB best bets. If you successfully parlay them you'd be looking at a big payout of nearly +500.

One pick we'll give away: The model is backing the Pirates (-120) against the Diamondbacks, saying Pittsburgh wins 60% of the time. 

The model has also locked in a must-see underdog play, creating an MLB parlay which pays out nearly +500! You ABSOLUTELY need to see it right now.

So what are the MLB best bets for Monday? ... Join SportsLine now to see who wins every single MLB game, all from the model that's on a 35-21 run on top-rated MLB picks!

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