There are 14 games on the Friday MLB schedule, and the focus this weekend turns to the AL Central. The second-place Cleveland Guardians host the division-rival Chicago White Sox as Cleveland tries to make up 2.5 games on the Central-leading Minnesota Twins. Chicago is in fourth place, 13 games behind Minnesota, which opens an interleague series at home against the Arizona Diamondbacks.

The Guardians vs. White Sox matchup is set for first pitch at 7:05 p.m. ET at Progressive Field. Cleveland is a -161 favorite (risk $161 to win $100), while the White Sox are priced at +137 in the SportsLine consensus MLB odds. The over/under for total runs scored is 8.5. The Twins are -130 favorites against Arizona (+111), with first pitch set for 8:10 p.m. ET. (See up-to-date lines for every game on our MLB odds page.)

The 14-game Friday MLB schedule offers plenty of opportunities for wagers, and combining your favorite picks into a parlay can pay off big. Before making any MLB picks or parlays, be sure to see the predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times. It went 331-285 on top-rated MLB money-line picks (+357) over the past two seasons. It entered Week 19 of the 2023 MLB season 49-39 on all top-rated MLB picks this season and has excelled on top-rated run-line picks, going 11-3 (+504).  Anybody following has seen big returns!

Now, the model has set its sights on the MLB schedule for Friday and has generated a four-leg parlay that would pay more than 7-1. The parlay doesn't start until 7:05 p.m. ET, giving you plenty of time to make your MLB picks.

We can tell you that one of the picks is the White Sox +1.5 runs (-152) against the Guardians, and the model has locked in three other selections for the parlay, all run-line underdogs! You ABSOLUTELY need to see the predictions before locking in any MLB picks of your own.

So which play is a MUST-BACK on Friday night's MLB schedule? And which teams do you need to include in your parlay for a payout of more than 7-1? ... Join SportsLine right now to find out which picks you should be all over on Friday, all from the model that is on an 11-3 run on top-rated run-line picks!