MLB odds, lines, picks: Advanced computer model includes the Giants in parlay for Wednesday, June 21, that would pay well over 7-1

The San Francisco Giants aim for their 10th straight victory when they host the National League West-rival San Diego Padres for the third contest of their four-game series on Wednesday (9:45 p.m. ET) at Oracle Park. San Francisco (41-32), which won each of the first two games of the set in walk-off fashion, has not lost since June 10 against the Chicago Cubs. San Diego (35-38) hopes to avoid its first three-game slide since dropping four in a row from May 16-20.

For Wednesday, San Diego is a -125 favorite in the latest Padres vs. Giants odds from Caesars Sportsbook, while San Francisco is a +105 underdog. The over/under for runs scored is 8. The game is one of seven on the MLB schedule for Wednesday evening. (See up-to-date lines for every game on our MLB odds page.)

Before making any MLB picks or parlays, be sure to see the predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times. It went 331-285 on top-rated MLB money-line picks (+357) over the past two seasons. It has opened the 2023 MLB season on a 35-26 roll on all-top rated MLB picks. Anyone who has followed it has seen profitable returns!

Now, the model has set its sights on the MLB schedule for Wednesday and has generated a three-leg parlay that would pay well over 7-1. The parlay doesn't start until 7:05 p.m. ET, giving you plenty of time to make your MLB picks.

We can tell you that one of the picks is the Giants (+105) to defeat the Padres, but the model has locked in two other selections for the parlay! You ABSOLUTELY need to see them before locking in any MLB picks of your own.

So which play is a MUST-BACK? And what teams do you need to include in your parlay for a payout of well over 7-1? ... Join SportsLine right now to find out which picks you should be all over on Wednesday, all from the model that is on a 35-26 run on top-rated MLB picks!