Angels two-way star Shohei Ohtani will look to stay hot when he takes the mound for the Los Angeles Angels on Wednesday against the Chicago White Sox at Angel Stadium in Anaheim, Calif. Ohtani (6-4, 2.90 ERA) has won three straight starts and has given up only one run in 20 innings. He will face Chicago's Michael Kopech (2-4, 2.59). 

Los Angeles is a -190 favorite in the latest Angels vs. White Sox odds from Caesars Sportsbook while Chicago is a +170 underdog. First pitch is set for 9:38 p.m. ET. The game is one of 15 on the MLB schedule for Wednesday. (See up-to-date lines for every game on our MLB odds page.)

Before making any MLB picks or parlays, be sure to see the predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times and is off to a strong start to the 2022 season. The model is on a 59-51 run on top-rated MLB money-line picks through 12 weeks. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win the World Series last season. Anybody who has followed the model has seen profitable returns.

Now, the model has set its sights on the MLB schedule for Wednesday, June 29. Using its top picks for the day, the model has generated a three-leg parlay that would pay 10-1! The parlay doesn't start until 8 p.m. ET, giving you plenty of time to make your MLB picks.

We can tell you that one of the picks is the Reds (+120) to beat the Cubs. But the model has two other picks, including a play on an even bigger underdog! You ABSOLUTELY need to see them before locking in any MLB picks of your own.

So which big underdog is a MUST-BACK? And what other teams do you need to include in your parlay for a payout of 10-1? ... Join SportsLine right now to find out which picks you should be all over on Wednesday, all from the model that is on a 59-51 roll on top-rated MLB money-line picks through 12 weeks!