Los Angeles Angels two-way star Shohei Ohtani tries to win three straight starts for the first time this season when the Angels host the Kansas City Royals at Angel Stadium in Anaheim, Calif. The reigning AL MVP, Ohtani (5-4, 3.28 ERA) is coming off a 5-2 win over Boston on June 9 and a 4-1 victory at Seattle on Thursday.

Los Angeles is a -245 favorite in the latest Angels vs. Royals odds from Caesars Sportsbook while Kansas City is a +205 underdog. First pitch is set for 9:49 p.m. ET. The game is one of 15 on the MLB schedule for Wednesday. (See up-to-date lines for every game on our MLB odds page.)

Before making any MLB picks or parlays, be sure to see the predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a strong start to the 2022 season. It's on a 56-47 roll on top-rated MLB money-line picks through 11 weeks. Anybody who has followed it has seen profitable returns.

Now, the model has set its sights on the MLB schedule for Wednesday, June 22. Using its top picks for the day, the model has generated a four-leg parlay that would pay almost 15-1! The parlay doesn't start until 7:05 p.m. ET, giving you plenty of time to make your MLB picks.

We can tell you that one of the picks is the Pirates (+115) to beat the Cubs. But the model has three other picks, including a play on an even bigger underdog! You ABSOLUTELY need to see them before locking in any MLB picks of your own.

So which big underdog is a MUST-BACK? And what other teams do you need to include in your parlay for a payout of almost 15-1? ... Join SportsLine right now to find out which picks you should be all over on Wednesday, all from the model that is on a 56-47 roll on top-rated MLB money-line picks through 11 weeks!