Mets vs. Cubs odds, line, prediction: 2026 MLB picks for Friday afternoon from proven model

The New York Mets travel to Wrigley Field on Friday afternoon to start a three-game series against the Chicago Cubs. The Mets have lost eight straight games and were swept by the Dodgers and the Athletics in their previous series. The Cubs took two of three games in their most recent series against the Phillies. The Mets (7-12), who have lost three straight on the road, are 4-6 on the road this season. The Cubs (9-9), who have three of their last four, are 4-5 on their home field.

First pitch from Wrigley Field in Chicago is set for 2:20 p.m. ET. The Cubs lead the all-time series 399-379, and the Cubs hold an even bigger advantage at home, 213-181 over the Mets. New York is a -139 favorite on the money line (risk $139 to win $100) in the latest Mets vs. Cubs odds, while the over/under, is 10.5.

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The model has simulated Mets vs. Cubs 10,000 times and the results are in. The model is going Under on the total, and is also says one side of the money line has ALL the value!

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