Louisville vs. North Carolina odds, prediction: 2026 Atlantic Coast Conference men's college basketball picks from proven model

The 16th-ranked North Carolina Tar Heels take on the 21st-ranked Louisville Cardinals in a key Atlantic Coast Conference matchup on Monday night. Louisville is coming off an 87-70 win over Georgia Tech on Saturday, while North Carolina topped Syracuse 77-64 that same day. The Cardinals (20-7, 9-5 ACC), who are tied with North Carolina for sixth in the conference, are 3-5 on the road this season. The Tar Heels (21-6, 9-5 ACC), who are 4-1 against ranked opponents, are 15-0 on their home court. Caleb Wilson (wrist) and James Brown (foot) have been ruled out.

Tipoff from the Dean E. Smith Center in Chapel Hill, N.C., is set for 7 p.m. ET. UNC leads the all-time series 20-8, including 11-5 since Louisville joined the ACC. Louisville is a 3.5-point favorite in the latest Louisville vs. North Carolina odds from DraftKings Sportsbook, while the over/under for total points scored is 162.5. 

Before making any Louisville vs. North Carolina picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and entered Week 17 on a sizzling 11-1 run on top-ranked over/under picks dating back to last year, and is on an 20-11 run on top-rated CBB side picks. Anyone following could have seen HUGE returns!

The model has simulated Louisville vs. North Carolina 10,000 times and the results are in. The model is leaning Under, and it also says one side of the spread hits well over 50% of the time!

So who wins Louisville vs. North Carolina, and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!