Lions vs. Cardinals odds, line, spread: Proven model reveals NFL picks, predictions for Week 15, 2021
TThe SportsLine Projection Model simulated the Week 15 game between Arizona and Detroit 10,000 times


The Detroit Lions will take on the Arizona Cardinals at 1 p.m. ET on Sunday at Ford Field. The Lions are 1-11-1 overall and 1-5 at home, while Arizona is 10-3 overall and 7-0 on the road.
Arizona is favored by 12.5 points in the latest Lions vs. Cardinals odds from Caesars Sportsbook, and the over-under is set at 47.5. Before you make any Cardinals vs. Lions picks and predictions, you'll want to see what the SportsLine Projection Model is saying.
The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters Week 15 of the 2021 season on an incredible 132-96 run on top-rated NFL picks that dates back to the 2017 season. The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY up.
Now, it has simulated Lions vs. Cardinals 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You absolutely need to see it before locking in your own picks.
So who wins Lions vs. Cardinals? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks... If you're already a member, see the picks below!
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