Lions vs. 49ers line, odds, start time, picks, best bets for Monday Night Football matchup from proven model

The Detroit Lions (13-2) and San Francisco 49ers (6-9) will end Week 17 when they clash on Monday Night Football. The Lions got back in the win column, defeating the Chicago Bears, 34-17, last Sunday. The 49ers have already been eliminated from playoff contention and dropped two straight games. Last week, the Miami Dolphins beat San Francisco, 29-17.

Kickoff from Levi's Stadium in San Francisco is set for 8:15 p.m. ET. The Lions are 3.5-point favorites in the latest Lions vs. 49ers odds from the SportsLine Consensus, while the over/under for total points scored is 50.5. The Lions are -203 money-line favorites, while the 49ers are +168 underdogs. 

Before making any Lions vs. 49ers picks, you NEED to see the NFL predictions from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 17 of the 2024 NFL season on a 28-12 hot streak on top-rated NFL picks this year -- a stunning 70% success rate! Longer term, it is on a 208-140 roll on top-rated NFL picks that dates back to the 2017 season and a 62-33 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone following has seen HUGE returns!

The model has simulated Lions vs. 49ers 10,000 times and the results are in. We can tell you the model is leaning Over the point total, and it also says one side of the spread cashes in OVER 50% of simulations!

Who wins Lions vs. 49ers on Monday Night Football, and which side of the spread cashes over 50% of the time? ... Join SportsLine right now to find out which side of the Lions vs. 49ers spread is a MUST-BACK, all from the model that is up well over $7,000 on its NFL picks!