Knicks vs. 76ers odds, line: Proven model reveals NBA picks for second round Game 1 matchup on Monday, May 4

Two longtime rivals will meet in the second round of the NBA playoffs 2026 as the New York Knicks face the Philadelphia 76ers, with Game 1 on Monday. New York (53-29) knocked off Atlanta in six games to reach the East semifinals for the fourth straight year. Philadelphia (45-37) rallied from a 3-1 hole to upend Boston to give the Sixers their first postseason series win since 2023. This is the 11th playoff matchup between the two franchises, with the 76ers holding the 6-4 edge.

Tipoff is at 8 p.m. ET from Madison Square Garden in New York City. New York is a 7.5-point favorite in the latest 76ers vs. Knicks odds from FanDuel Sportsbook, while the over/under for total points scored is 212.5.

Before making any Knicks vs. 76ers picks, you NEED to see what the SportsLine Projection Model has to say.

SportsLine's model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past eight-plus seasons. The model entered the second full week of the 2026 NBA playoffs on a sizzling 25-9 roll (74%) on top-rated NBA spread picks this season. Anyone following could have seen HUGE returns!

The model has simulated 76ers vs. Knicks 10,000 times and the results are in. The model is going Over on the point total, and it also says one side of the spread hits in over 60% of simulations!

Who wins Knicks vs. Sixers, and which side of the spread hits over 60% of the time? ... Join SportsLine right now to find out which side of the Sixers vs. Knicks spread you should be all over, all from the model on a 25-9 roll on top-rated NBA picks!