The Houston Cougars and Tulane Green Wave play their American Athletic Conference opener when the two teams collide on Friday at TDECU Stadium in Houston. The Cougars (2-2) rebounded from a two-game losing skid with a win over crosstown rival Rice last week. They entered the season as the favorite to win the AAC. Meanwhile the Green Wave (3-1), blew a halftime lead against Southern Miss, dropping their first game of the season.

Kickoff is 7 p.m. ET. The Cougars are 4-point favorites in the latest Houston vs. Tulane odds from Caesars Sportsbook, while the over/under for total points scored is 53. (See up-to-date odds for every game this week on our college football odds page.)

Before you make any Tulane vs. Houston picks or college football predictions, you NEED to see the predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of more than $3,100 for $100 players on its top-rated college football picks against the spread. Anyone who has followed the model has seen huge returns.

The model knows that Houston's defense has shown an elite ability of getting to the quarterback. Senior end D'Anthony Jones ranks third nationally with a 91.4 pass rush grade from Pro Football Focus. Last season against Tulane the Cougars had eight sacks as a team, which was tied for the third most ever in an AAC game.

The model also has taken into account that Tulane has been stingy on defense this season. The Green Wave lead the country in passing defense (102.5 yards per game) and rank fourth in total defense (228.8). Earlier this season they limited Alcorn State to 109 total yards, including just 49 through the air, in a 52-0 victory.

Now, the model has set its sights on Houston vs. Tulane. We can tell you it is leaning Over the total, and it also says one side of the spread hits in well over 50% of simulations! You ABSOLUTELY need to see it before locking in any college football picks.

Who wins Tulane vs. Houston? And which side of the spread hits in well over 50% of simulations? ... Join SportsLine right now to find out which side of the Houston vs. Tulane spread you should be all over Friday, all from the model on a roll on college football picks!