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The 17th-ranked Houston Cougars battle the Colorado Buffaloes in a key Big 12 Conference matchup on Friday night. Houston is coming off a 31-24 win over Cincinnati on Saturday, while Colorado dropped a 20-10 decision at Arizona State that same day. The Cougars (7-2, 4-2 Big 12), who are tied for third in the conference, are 2-2 on the road this season. The Buffaloes (3-6, 1-5 Big 12), who are tied for 14th in the league, are 2-2 on their home field in 2026. Visit our Kalshi promo code review and get a $55 bonus after $25+ in trades with the Kalshi promo code SPORTSLINE55:
Kickoff is set for 10:15 p.m. ET at Folsom Field in Boulder, Colo. The all-time series is tied 1-1, but Houston won last year's meeting 36-20. The Cougars are 10.5-point favorites, with the over/under at 51.5 in the latest Houston vs. Colorado odds.
Before making any Houston vs. Colorado picks, check out the college football predictions from the SportsLine Projection Model.
The model simulates every FBS game 10,000 times, seeking the best values for spread, money-line and over/under bets.
The model has simulated Houston vs. Colorado 10,000 times and the results are in. The model is going Over on the total, and it also says one side of the spread hits in well over 50% of simulations!
So who wins Houston vs. Colorado, and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that gives the best value on top-rated CFB picks!
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Written by Daniel Kohn
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