The Cleveland Guardians (67-47) and the Minnesota Twins (63-50) collide in the first game of a doubleheader on Friday. Minnesota heads into this contest on a two-game losing streak. On Wednesday, the Chicago Cubs topped the Twins 8-2. On the other side, Cleveland is on a five-game skid. The Arizona Diamondbacks outmatched Cleveland 5-3 on Aug. 7. 

First pitch is scheduled for 2:10 p.m. ET from Target Field in Minnesota. The Twins are the -167 money-line favorites (risk $167 to win $100) in the latest Guardians vs. Twins odds, while Cleveland is a +139 underdog. The over/under for total runs scored is 8.5 in the latest MLB odds via SportsLine consensus. 

Before making any Guardians vs. Twins picks or MLB predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times. Entering Week 20 of the MLB season, it's on a 24-12 roll on top-rated run-line picks (+777) that dates back to last season. Anybody following has seen STRONG returns!

The model knows Cleveland third baseman Jose Ramirez is an excellent hitter for this squad. Ramirez has outstanding pop in his swing and has been a solid run producer. He's second in the MLB in RBI (96) and fifth in home runs (30). He went 1-of-4 in his last game, smashing one home run. 

The model also knows Minnesota first baseman Carlos Santana is a veteran slugger in the lineup. Sanatana stays relaxed at the plate with solid power. He has a .244 batting average with 14 home runs and 48 RBI. Santana had two base hits in his last game.

The model has simulated Guardians vs. Twins 10,000 times and the results are in. We can tell you the model is leaning Over on the run total, and it also says one side of the money line has ALL the value!

Who wins Guardians vs. Twins, and which side of the money line has ALL the value? ... Join SportsLine right now to find out which side of the money line you should be all over, all from the model on a 24-12 roll on top-rated MLB run-line picks!