Guardians vs. Tigers odds, line, prediction: 2026 MLB picks for Thursday, May 21, from proven model

The Cleveland Guardians go for the four-game series sweep when they battle the American League Central Division-rival Detroit Tigers on Thursday afternoon. Cleveland is coming off a 3-2 win over Detroit in 10 innings on Wednesday night. The Guardians (29-22), who have won five in a row, are 14-12 on the road this season. The Tigers (20-30), who have dropped five straight, are 13-11 on their home field in 2026.

First pitch from Comerica Park in Detroit is set for 1:10 p.m. ET. The Guardians lead the all-time series 1,170-1,168, and have won eight of the last 11 meetings. Detroit is a -115 favorite on the money line (risk $115 to win $100) in the latest Guardians vs. Tigers odds, while the over/under, is 7.5. 

Before making any Guardians vs. Tigers picks, or MLB predictions, you NEED to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times and enters Week 9 of the MLB season on a sizzling 12-1 run on all top-rated MLB picks. It also excelled at making home run prop picks in 2025, returning nearly 30 units of profit. Anybody following could have seen strong returns!   

The model has simulated Guardians vs. Tigers 10,000 times and the results are in. The model is going Over on the total, and is also says one side of the money line has ALL the value!

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