The Cleveland Guardians go for the four-game series sweep when they battle the American League Central Division-rival Detroit Tigers on Thursday afternoon. Cleveland is coming off a 3-2 win over Detroit in 10 innings on Wednesday night. The Guardians (29-22), who have won five in a row, are 14-12 on the road this season. The Tigers (20-30), who have dropped five straight, are 13-11 on their home field in 2026.
First pitch from Comerica Park in Detroit is set for 1:10 p.m. ET. The Guardians lead the all-time series 1,170-1,168, and have won eight of the last 11 meetings. Detroit is a -122 favorite on the money line (risk $122 to win $100) in the latest Guardians vs. Tigers odds, with Cleveland priced at +103 (risk $100 to win $103). The over/under is 7.