The Cleveland Guardians and St. Louis Cardinals meet in the third and deciding game of their interleague series on Wednesday afternoon. St. Louis defeated Cleveland 6-5 in 10 innings on Tuesday night. The Guardians (10-8), who have lost three of five, are 6-6 on the road this season. The Cardinals (9-8), who snapped a three-game losing streak, are 6-5 on their home field in 2026.
First pitch from Busch Stadium in St. Louis is set for 1:15 p.m. ET. The Guardians lead the all-time series 24-19, including a 14-10 edge in games played at Busch Stadium. St. Louis is a -114 favorite on the money line (risk $114 to win $100) in the latest Guardians vs. Cardinals odds, while the over/under, is 8.5.
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Written by Daniel Kohn
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