Giants vs. Reds odds, picks: Advanced computer MLB model releases selections for Sunday morning matchup

The San Francisco Giants and Cincinnati Reds will start the final game of their three-game series not long after their morning coffee Sunday when they face off at Great American Ball Park. The game is the first of the 18-week streaming-only Sunday Leadoff Series. The games start at 11:30 a.m. ET and give the featured teams an exclusive window until 1:30 p.m. ET. The Reds (16-30) won the first game of the series 5-1 on Friday. Then they eked out a 3-2 win against the the Giants (24-21) when they nailed the tying run at the plate to end the game on Saturday.   

San Francisco is listed as a -145 favorite (risk $145 to win $100) at Caesars Sportsbook, while the Over-Under is set at nine (see up-to-date odds for every game this week on our MLB odds page). 

Before you lock in any Reds vs. Giants picks, you NEED to check out the MLB predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a strong start to the 2022 season. It's on a 41-30 roll on top-rated MLB money-line picks through seven weeks, returning almost $600 for $100 players. Anyone following it has seen HUGE returns!

The model knows the Giants have the advantage on offense and that expected Reds starter Tyler Mahle comes in off his worst start of the season. The right-hander allowed eight runs and two homers in that outing and has had major issues with walks. Now he faces a Giants team that is second in MLB in walks (3.9 per game) and has  scored the third-most runs (226). Joc Pederson has 11 home runs, and Wilmer Flores has 10 doubles and they have a combined 51 RBI. Thairo Estrada has team-high 41 hits.    

The model also has considered that the Reds have been on a strong run after getting off to an abysmal 3-22 start to the season. They are 13-8 since then, and they face a San Francisco pitching staff that has allowed the third-most hits in the majors (212) and has the third-worst WHIP (1.36). Giants starter Alex Cobb has a 6.25 ERA and the bullpen ERA is 4.53 ERA, fifth-worst in the majors. Three Reds have at least 10 doubles, including Brandon Drury, who also has eight homers and a team-high 26 RBI. 

Now, the model has set its sights on Sunday's Giants vs. Reds matchup. We can tell you the model is leaning Over the total, and it also says one side of the money line has ALL the value! You ABSOLUTELY need to see it before locking in any MLB picks.

Who wins Reds vs. Giants on Sunday in Cincinnati? And which team has ALL the value on the money line? ... Join SportsLine right now to find out which side of the Giants vs. Reds matchup you should be all over Saturday, all from the model on a roll on MLB picks!