Duke vs. Ole Miss prediction, betting odds: 2025 Gator Bowl picks, college football bets from proven model

The No. 14 Ole Miss Rebels and Duke Blue Devils are set to square off in an ACC vs. SEC battle in the 2025 Gator Bowl on Thursday, Jan. 2. Both teams will look to secure their 10th win of the season with a victory on Thursday. The Blue Devils (9-3) were one of the biggest surprises in 2024 and enter Thursday's tilt having won three straight. The Rebels, meanwhile, fell short of the College Football Playoffs but will look to win their second bowl game in a row. 

Kickoff is set for 8 p.m. ET on Thursday, 30 minutes later than originally scheduled, at EverBank Stadium in Jacksonville. Ole Miss is favored by 17.5 points in the latest Ole Miss vs. Duke odds via SportsLine consensus, while the over/under is 50.5 points. 

Before entering any Duke vs. Ole Miss picks or 2025 Gator Bowl bets, you'll want to see the college football predictions from the advanced computer model at SportsLine.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of well over $2,000 for $100 players on its top-rated college spread football picks, and it is 43-35 on top-rated picks during the 2024 season. It also nailed all four winners in the first round of the College Football Playoff. Anyone following has seen impressive returns!

Now, the model has simulated Ole Miss vs. Duke 10,000 times and the results are in. We can tell you that the model is leaning Under on the point total, and it's also generated a point-spread pick that is hitting in well over 50% of simulations!

So who wins Ole Miss vs. Duke in the Gator Bowl, and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks!