The Florida State Seminoles (1-5, 1-1) look to snap a two-game losing streak when they take on the Duke Blue Devils (5-1, 1-1) in an ACC matchup on Friday. Kickoff at Wallace Wade Stadium in Durham, N.C. is scheduled for 7 p.m. ET. The Noles are coming off a bye and were blown out by Clemson in their last game, losing 29-13. Duke is also coming off a bye and will be looking to bounce back from its first loss of the season. On Oct. 5, the Blue Devils suffered a 24-14 loss to Georgia Tech. Quarterback DJ Uiagalelei (hand) remains sidelined for Florida State.

The Blue Devils are 3-point favorites in the latest Florida State vs. Duke odds via SportsLine consensus, while the over/under for total points scored is 42.5. Duke is a -146 (risk $146 to win $100) favorite on the money line, with Florida State listed as a +121 underdog (see up-to-date odds for every game this week on our college football odds page). 

Before you make any Duke vs. Florida State picks or any other college football predictions, you NEED to see which side proven SportsLine expert Jimmie Kaylor is on. 

Kaylor is a NFL, college football and DFS expert for SportsLine, who has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America. His background as a former college football All-American and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks. He has his finger on the pulse of the college football landscape and has been cashing in big for the last two years. 

Kaylor has destroyed the books in college football the last two seasons, netting a whopping 53.9 units while posting a 163-102-2 record since Week 1 of the 2023 season. Anyone who followed his picks finished the season WAY UP!

Now, Kaylor has locked in a confident against-the-spread pick for Florida State vs. Duke in their Week 8 ACC matchup. We can tell you he's leaning Over on the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

Who wins Duke vs. Florida State in their Week 8 matchup in Durham and what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to see which side of the spread to jump on, all from the expert who is 163-102-2, returning $5,390 for $100 bettors, betting on college football since Week 1 of the 2023 season, and find out!

Be sure to follow Jimmie (@jimmiekaylor) on Twitter for notifications about picks changes/updates