The reigning champion Los Angeles Dodgers will begin defense of their title on 2026 MLB Opening Day with a matchup with the Arizona Diamondbacks on Thursday. Los Angeles (93-69) is aiming to end the year with the first MLB three-peat since the Yankees (1998-2000). The Diamondbacks (80-82) are hoping to end the season with a postseason appearance after missing out on the last two years, which came after a World Series appearance in 2023. L.A. will start Yoshinobu Yamamoto (12-8, 2.49 ERA), while the Dbacks will roll with Zac Gallen (13-15, 4.83 ERA).
First pitch is at 8:30 p.m. ET from Dodger Stadium in Los Angeles. The latest Dodgers vs. Diamondbacks odds list L.A. as the -269 favorite on the money line (risk $269 to win $100), with Arizona at +218 (risk $100 to win $218). The over/under for total runs is 9.