The Los Angeles Dodgers and Chicago Cubs meet in the MLB regular-season opening 2025 Tokyo Series on Tuesday. Los Angeles is coming off a World Series championship, while Chicago tied with St. Louis for second in the National League Central Division last year. Japanese native and right-hander Yoshinobu Yamamoto (7-2, 3.00 ERA) is the starter for the Dodgers, while the Cubs are expected to go with left-hander Shota Imanaga (15-3, 2.91 ERA), also from Japan. The Dodgers will be without Mookie Betts (illness).
First pitch is scheduled for 6:10 a.m. ET at the Tokyo Dome in Tokyo, Japan. The Dodgers are the -160 money-line favorites (bet $160 to win $100) in the latest Dodgers vs. Cubs odds, while the Cubs are +135 underdogs (bet $100 to win $135). The over/under for total runs scored is 8 in the latest MLB odds via SportsLine consensus.
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