Cubs vs. Phillies odds, line, prediction: 2026 MLB picks for Wednesday, April 15 from proven model

A rubber match between NL squads with the same records is on tap for Wednesday's MLB schedule as the Chicago Cubs visit the Philadelphia Phillies. Chicago (8-9) defeated Philly on Tuesday after dropping Monday's opener. Philadelphia (8-9) has now alternated losses with wins over its last five games. Shota Imanaga (0-1, 2.81 ERA) will take the mound for the Cubs, and he'll be countered by the Phillies' Jesus Luzardo (1-2, 6.23 ERA).

First pitch is at 6:40 p.m. ET from Citizens Bank Park in Philadelphia. The latest Phillies vs. Cubs odds list Philly as the -137 favorite on the money line (risk $137 to win $100). The over/under for total runs is 8.5.

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The model has simulated Phillies vs. Cubs 10,000 times and the results are in. The model is going Over on the total, and is also says one side of the money line has ALL the value!

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