Week 17 of the 2022 NFL season kicks off when the Dallas Cowboys visit the Tennessee Titans on Thursday Night Football. The Cowboys (11-4) sit in second place in the NFC East, two games behind Philadelphia with two games remaining, and already have clinched a spot in the playoffs. The Titans (7-8) are tied with Jacksonville for the lead in the AFC South and could be without running back Derrick Henry, who is doubtful with a hip injury.

Kickoff is 8:15 p.m. ET. Dallas is a 14-point favorite in the latest Cowboys vs. Titans odds from Caesars Sportsbook, while the over/under for total points scored is 40.

Before you make any Titans vs. Cowboys picks or NFL Week 17 predictions, you need to see what SportsLine senior analyst Larry Hartstein has to say.

A former lead writer for Covers and The Linemakers, Hartstein combines a vast network of Vegas sources with an analytical approach he honed while working for Pro Football Focus. He entered the 2022 NFL season 427-344 all-time on NFL side picks (plus $3,764 for $100 players), including 394-330 against the spread. Hartstein went 68-50 ATS and 8-3 on money-line plays last season for a profit of $1,552.

Hartstein also is 13-3 on his last 16 against-the-spread picks involving the Cowboys, meaning he's uniquely qualified to make this pick.

Hartstein knows that Dallas faces a Tennessee team that has little motivation to play well on Thursday. The outcome of the game will not affect the Titans' playoff chances. As a result, the Titans could elect to limit the playing time for key players on TNF in preparation for next week.

But Hartstein also knows that Tennessee squares off against a Dallas team that is below-average stopping the run. The Cowboys allow 130.0 rushing yards per game, which ranks 22nd in the NFL. That bodes well for a Titans offense that runs for 125.8 yards per game, the 12th-most in the league.

Now, Hartstein has locked in another confident against-the-spread pick for Cowboys vs. Titans. We can tell you he's leaning Over on the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

Who wins Cowboys vs. Titans on Thursday Night Football? And what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to see which side of the Titans vs. Cowboys spread to jump on, all from the expert who's an outstanding 13-3 on against-the-spread picks involving Dallas!