Colts vs. Commanders prediction, odds, line, spread: Proven model reveals NFL picks, best bets for Week 8, 2022

The Week 8 NFL schedule features a battle between backup quarterbacks turned starters when Taylor Heinicke and the Washington Commanders (3-4) hit the road to take on Sam Ehlinger and the Indianapolis Colts (3-3-1) at Lucas Oil Stadium in Indianapolis. Heinicke replaced Carson Wentz and led the Commanders to a 23-21 win over the Green Bay Packers in Week 7, while Ehlinger replaces Matt Ryan and will be making his first start of the 2022 season.

Kickoff is at 4:25 p.m. ET. Indianapolis is favored by 3 points in the latest Commanders vs. Colts odds from Caesars Sportsbook, and the over/under is set at 39.5 points. Before making any Colts vs. Commanders picks or predictions, you'll want to see what the SportsLine Projection Model is saying.

The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 8 of the 2022 NFL season on an incredible 148-107 run on top-rated NFL picks that dates back to the 2017 season. The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP!

Now, it has simulated Colts vs. Commanders 10,000 times and the results are in. We can tell you that the model is leaning Over on the point total, and it also says one side of the spread hits more than 50% of the time. You absolutely need to see it before locking in your own picks.

So who wins Commanders vs. Colts? And which side of the spread hits more than 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks.