Colts vs. Bills odds, line: Proven model reveals NFL picks, predictions for Week 10 matchup
The SportsLine Projection Model has simulated Indianapolis Colts vs. Buffalo Bills 10,000 times and revealed its Week 10 NFL picks
The Indianapolis Colts (4-5) host the Buffalo Bills (7-2) in an NFL Week 10 battle on CBS and . Kickoff from Lucas Oil Stadium in Indianapolis is 1 p.m. ET. The Bills are 4.5-point favorites in the latest Colts vs. Bills odds via SportsLine consensus, and the over/under for total points scored is 46.5. The Bills are -227 money line favorites (risk $227 to win $100), while the Colts are +187 underdogs. You may be able to .
