There are five matchups of AP Top 25 teams during the Week 5 schedule, and the action gets started early with No. 7 Kentucky traveling to No. 14 Ole Miss. The Week 5 college football odds from Caesars Sportsbook list the Rebels as 6.5-point favorites in that one. Elsewhere in the SEC, No. 2 Alabama travels to No. 20 Arkansas (+15.5) in the 3:30 p.m. ET SEC on CBS matchup. In the ACC, it's No. 22 Wake Forest vs. No. 23 FSU (-6) and No. 10 NC State vs. No. 5 Clemson (-6.5). And Big 12 contenders square off as No. 9 Oklahoma State goes to No. 16 Baylor (-2.5). 

Before making any college football picks for those games or others in Week 5, be sure to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of more than $3,100 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen HUGE returns!

Now, it has studied the latest college football odds from Caesars (see the latest college football lines for each matchup this week on our college football odds page), simulated every single play for Week 5 of FBS college football, and the results are in. 

One of the college picks the model is high on in Week 5: No. 18 Oklahoma (-5) easily covers at TCU in a noon ET kickoff on Saturday. The Sooners appear to be undervalued in this spot after being upset by Kansas State last week. They cover well over 60% of the time, while the Under (69) hits almost 60% of the time.

Another prediction: No. 13 Oregon (-17) handles the large spread against a struggling Stanford squad in an 11 p.m. ET start in Eugene. The Ducks win by 19 points in the simulations, covering the spread well over 50% of the time. 

The model has also made the call on who wins and covers in every other FBS matchup, and it's calling for a top-10 team to go down HARD in an outright upset! 

So which college football teams should you back this week? And which top-10 favorite down HARD? ... Join SportsLine now to see who wins and covers every single game, all from the model that has returned more than $3,100 in profit on top-rated ATS picks over the past six-plus seasons!