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College football odds, lines, spreads: Picks, predictions, betting advice for Week 5, 2021 from proven model

The SportsLine Projection Model, which has generated almost $3,300 for $100 college football bettors over the past five-plus years, has revealed its college football picks for Week 5
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A pair of massive SEC matchups highlight the Week 5 college football schedule. No. 1 Alabama is a 14.5-point favorite at Caesars Sportsbook against Ole No. 12 Miss in the 3:30 p.m. ET SEC on CBS matchup. No. 2 Georgia, meanwhile, is -16.5 against No. 8 Arkansas in a noon ET kick on Saturday. Outside the SEC, the headliner is No. 9 Notre Dame against No. 7 Cincinnati (-2).

Before making any college football picks for those games or others in Week 5, be sure to see what the SportsLine Projection Model has to say. 

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,300 for $100 players on its top-rated college football picks against the spread. After going a sizzling 9-3 in Week 4, It also enters Week 5 of the 2021 season on a 81-61 run on all top-rated college football picks. Anyone who has followed it has seen HUGE returns.

Now, it has studied the latest college football odds from Caesars (see the latest college football lines for each matchup this week on our college football odds page), simulated every single play for Week 5 of FBS college football, and the results are in. 

One of the college picks the model is high on in Week 5: No. 10 Florida covers (-7.5) against Kentucky in an SEC East clash. The Gators have dominated this series historically, losing just once to Kentucky since 1986. Coming off covers against Alabama and Tennessee, the model says the Gators cover over 50 percent of the time against the Wildcats. 

Another prediction: Cincinnati gets the job done against Notre Dame, covering the line (-2) well over 50 percent of the time. 

The model has also made the call on who wins and covers in every other FBS matchup, and it is calling for a favored Top 25 team to get stunned. You ABSOLUTELY need to see its college football picks before locking in any of your own. 

So which college football teams should you back this week? And which Top 25 favorite goes down HARD? ... Join SportsLine now to see who wins and covers every single game, all from the model that has returned almost $3,300 in profit on top-rated ATS picks over the past five-plus seasons!

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SportsLine Staff