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College football odds, lines, spreads: Picks, predictions, betting advice for Week 4, 2022 from proven model

The SportsLine Projection Model, which has generated more than $3,300 for $100 college football bettors over the past six-plus years, has revealed its college football picks for Week 4
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A couple marquee SEC games highlight the Week 4 college football schedule as No. 11 Tennessee hosts No. 20 Florida in an SEC on CBS matchup and No. 10 Arkansas heads to No. 23 Texas A&M. The Week 4 college football odds from Caesars Sportsbook lists the Volunteers at -10, while the Aggies are -2.5. Elsewhere, No. 3 Ohio State is -18 against Wisconsin, No. 2 Alabama is a massive 40.5-point favorite against Vanderbilt, No. 5 Clemson is -7 against No. 21 Wake Forest and No. 6 Oklahoma is -13 against Kansas State.

Before making any college football picks for those games or others in Week 4, be sure to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of more than $3,300 for $100 players on its top-rated college football picks against the spread. It entered Week 4 of the 2022 college football season on a 51-43 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen HUGE returns!

Now, it has studied the latest college football odds from Caesars (see the latest college football lines for each matchup this week on our college football odds page), simulated every single play for Week 4 of FBS college football, and the results are in. 

One of the college picks the model is high on in Week 4: No. 22 Texas (-7) covers on the road against Texas Tech in a 3:30 p.m. ET matchup on Saturday. The Longhorns, who are 3-0 ATS this season, drop 42 points on the Red Raiders in the simulations, helping Texas cover almost 60% of the time. 

Another prediction: No. 7 USC (-6) easily covers at Oregon State in a 9:30 p.m. ET kickoff in Corvallis. The Trojans almost hit 50 points in the simulations as they cover more than 70% of the time. The Over 70.5, meanwhile, hits almost 60% of the time. 

The model has also made the call on who wins and covers in every other FBS matchup, and it's calling for a Top 25 team to go down HARD in an outright upset! You ABSOLUTELY need to see its Week 4 college football picks before locking in any of your own. 

So which college football teams should you back this week? And which Top 25 favorite down HARD? ... Join SportsLine now to see who wins and covers every single game, all from the model that has returned more than $3,300 in profit on top-rated ATS picks over the past six-plus seasons!

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SportsLine Staff