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Lane Kiffin makes his LSU head coaching debut as the 11th-ranked Tigers battle the Clemson Tigers in a Week 1 college football matchup on Saturday. Clemson, who tied for seventh in the Atlantic Coast Conference at 4-4, were 7-6 overall in 2025. LSU, meanwhile, was 10th in the Southeastern Conference and 7-6 overall last season. LSU leads the all-time series 4-1, including a 17-10 win last year. Visit our DraftKings promo code review and get $200 in bonus bets as a new user after $5+ in wagers here:
Kickoff is set for 7:30 p.m. ET at Tiger Stadium in Baton Rouge, La. LSU is a 10-point favorites in the latest Clemson vs. LSU odds. The over/under for total points is 50.5.
Before making any Clemson vs. LSU picks, check out what SportsLine college football expert Eric Cohen has to say.
A former Phoenix sports radio host and TV analyst, Cohen joined SportsLine in 2022 and quickly became a fixture on "Early Edge" programming. He has hosted and appeared regularly on CFB, NFL and golf shows. Entering the 2026 season, Cohen was 90-68 (57 percent) on college football ATS picks, returning $1,636 to $100 players. He is also 5-1 (+400) on his last six picks in LSU games. Anyone following could have seen HUGE returns!
Now, Cohen has locked in another confident pick for Clemson vs. LSU. We can tell you he's leaning Under on the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.
So who wins Clemson vs. LSU on Saturday, and what x-factor makes one side of the spread hit HARD? Join SportsLine RIGHT NOW to see which side of the Clemson vs. LSU line to back, all from the expert who is up +400 on his last six LSU picks!
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Written by Daniel Kohn
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