Cavaliers vs. Knicks odds, line: Proven model reveals picks for NBA Eastern Conference final Game 2 matchup on Wednesday, May 21

The New York Knicks mounted a historic comeback to win the first game of the 2026 NBA Eastern Conference Finals, stunning the Cavaliers in overtime. The Knicks came back from 22-points down with less than 8 minutes remaining to force overtime and outscore the Cavaliers 14-3 in overtime. New York can protect home-court on Thursday and take a 2-0 lead into Cleveland.

Tipoff from Madison Square Garden in New York City is set for 8 p.m. ET. The Thunder are 6.5-point favorites in the latest Cavaliers vs. Knicks odds from FanDuel Sportsbook, while the over/under for total points scored is 215.5. 

Before making any Cavaliers vs. Knicks picks, you NEED to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past eight-plus seasons. The model entered the conference finals of the 2026 NBA playoffs on a sizzling 26-10 roll (72%) on top-rated NBA spread picks this season. Anyone following its NBA betting advice at sportsbooks and on betting apps could have seen HUGE returns!

The model has simulated Cavaliers vs. Knicks 10,000 times and the results are in. The model is going Over on the point total, and it also says one side of the spread is the better value!

Who wins Cavaliers vs. Knicks, and which side of the spread is the better value? ... Join SportsLine right now to find out which side of the spread you should be all over, all from the model on a 26-10 roll on top-rated NBA picks!