An interleague clash takes place on Sunday Night Baseball as the Detroit Tigers host the St. Louis Cardinals. Both teams are 4-4 in the 2026 MLB season, with Detroit 2-0 at home and St. Louis 0-2 on the road. The Tigers have claimed the first two games of this three-game set, shutting out the Cardinals 4-0 on Friday and then prevailing 11-6 on Saturday. Kyle Leahy (0-1, 7.20 ERA) will start for the Cards, with Keider Montero making his season debut for the Tigers.
First pitch is at 7:20 p.m. ET from Comerica Park in Detroit. The latest Tigers vs. Cardinals odds list Detroit as the -143 favorite on the money line (risk $143 to win $100). The Cardinals are +121 underdogs (risk $100 to win $121). The over/under for total runs is 8.