The St. Louis Cardinals (47-40) and the Pittsburgh Pirates (37-50) link up in their series finale on Wednesday afternoon. The Pirates have won two straight games and are coming off a 1-0 victory over the Cardinals on Tuesday night. Sonny Gray (8-2, 3.36 ERA) gets the nod for St. Louis. Mitch Keller (2-10, 3.90 ERA) takes the hill for the Pirates.
First pitch is scheduled for 12:35 p.m. ET at PNC Park in Pittsburgh. The Cardinals are the -124 money-line favorites (bet $124 to win $100) in the latest Cardinals vs. Pirates odds, while the Pirates are +104 underdogs (bet $100 to win $104). The over/under for total runs scored is 8 in the latest MLB odds.
Before you make any Cardinals vs. Pirates picks or MLB predictions, you need to see what the SportsLine Projection Model has to say.
The SportsLine Projection Model simulates every MLB game 10,000 times. It entered Week 15 of the 2025 MLB season on a profitable 39-30 run on top-rated MLB sides picks. It has excelled making home run prop picks this season, returning more than 24 units of profit. Anybody following could have seen strong returns!
The model has simulated Cardinals vs. Pirates 10,000 times and the results are in. We can tell you the model is going Over on the run total, and it also says one side of the money line has all the value!
Who wins Cardinals vs. Pirates, and which side of the money line has all the value? ... Join SportsLine right now to find out which side of the money line you should be all over, all from the model on a 39-30 roll on top-rated MLB picks!
GET VEGAS EXPERT PICKS FOR NFL, MLB, NBA, CBB, GOLF, NHL, HORSE RACING AND MORE - PLUS ADVANCED COMPUTER SIMULATIONS, WINNING TOOLS, AND MORE!
Written by Richard Louis
View expert profile
