Cardinals vs. Marlins odds, line, prediction: 2026 MLB picks for Wednesday, April 22 from proven model

A pair of National League squads conclude a three-game series on Wednesday's MLB schedule as the Miami Marlins host the St. Louis Cardinals. Miami (11-13) won Monday's opener before dropping Tuesday's contest, and the Marlins haven't won a series since taking their first two of the year. St. Louis (14-9) has now won six of its last seven and is looking to win its third straight road series. Janson Junk (0-2, 4.50 ERA) will start for the Marlins, countered by St. Louis' Kyle Leahy (2-2, 5.21 ERA).

First pitch is at 12:10 p.m. ET from loanDepot Park in Miami. The latest Marlins vs. Cardinals odds list Miami as the -133 favorite on the money line (risk $133 to win $100). The over/under for total runs is 8.5.

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The model has simulated Marlins vs. Cardinals 10,000 times and the results are in. The model is going Over on the total, and is also says one side of the money line has ALL the value!

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