Cardinals vs. Cubs odds, prediction, time: 2026 MLB picks for Friday, July 3 from proven model

The St. Louis Cardinals visit the Chicago Cubs in an NL Central rivalry game on Friday. St. Louis (44-39) has been competitive in the division race, while Chicago (49-38) holds the better record and has the home-field advantage at Wrigley. The Cubs have dominated the Over/Under this season, going 47-39-1, while the Cardinals lean the other way at 34-44-5.

First pitch is at 4:05 p.m. ET in Chicago. The latest Cardinals vs. Cubs odds list Chicago as the -131 favorite (risk $131 to win $100). The over/under for total runs is 10.5.

Before making any Cardinals vs. Cubs picks or MLB predictions, you NEED to see what the SportsLine Projection Model has to say.

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The model has simulated Cardinals vs. Cubs 10,000 times and the results are in. The model is going Under on the total, and is also says one side of the money line has ALL the value!

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