The Chicago Cubs look to get back on track when they battle the rival St. Louis Cardinals in a key National League Central matchup on Friday afternoon. Chicago dropped a 7-0 decision at Washington on Thursday, while St. Louis downed Philadelphia 7-1 on Wednesday. The Cardinals (61-60), who are third in the division, are 29-26 on the road this season. The Cubs (71-51), who are second in the NL Central, are 35-24 on their home field in 2026.
First pitch from Wrigley Field in Chicago is set for 2:20 p.m. ET. The Cubs have won four of the last five meetings, but the teams have split 10 games this season. Chicago is a -179 favorite on the money line (risk $179 to win $100) in the latest Cardinals vs. Cubs odds, while the over/under, is 8. Before making any Cardinals vs. Cubs picks, or MLB predictions, you NEED to see what the SportsLine Projection Model has to say.
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Written by Daniel Kohn
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