An NFC South battle is on tap between the Tampa Bay Buccaneers and the Carolina Panthers at 4:25 p.m. ET on Sunday at Raymond James Stadium. Tampa Bay is 12-4 overall and 6-1 at home, while Carolina is 5-11 overall and 3-5 on the road. 

Tampa Bay is favored by eight points in the latest Buccaneers vs. Panthers odds from Caesars Sportsbook, and the over-under is set at 41.5. Before you make any Panthers vs. Buccaneers picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The model, which simulates every NFL game 10,000 times, is up over $7,200 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters Week 18 of the 2021 season on an incredible 135-96 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP!

Now, it has simulated Buccaneers vs. Panthers 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in over 50 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Buccaneers vs. Panthers? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks... If you're already a member, see the picks below!