The Milwaukee Brewers begin their quest for a second consecutive division title when they visit the National League Central-rival Chicago Cubs on Thursday in the 2022 MLB season opener for both teams. First pitch from Wrigley Field is scheduled for 2:20 p.m. ET.

Milwaukee is listed as a -180 favorite (risk $180 to win $100) on the money line in the latest Brewers vs. Cubs odds from Caesars Sportsbook, while the over-under for total runs scored is nine (see the latest lines for every game on our MLB odds page).

Before making any Cubs vs. Brewers picks, you NEED to see the latest MLB predictions from the SportsLine Projection Model.

This model, which simulates every game 10,000 times, enters the 2022 MLB season coming off a 209-178 record on top-rated MLB money-line picks in 2021, returning over $700 for $100 players. Anyone following it has seen HUGE returns!

The model knows Milwaukee hopes to get off to a strong start behind 2021 NL Cy Young Award winner Corbin Burnes, who went 11-5 with an ML-best 2.43 ERA and 0.94 WHIP in 28 outings last season. The 27-year-old right-hander was fifth in baseball with 234 strikeouts and tied the major-league record by fanning 10 consecutive batters in a victory against the Cubs on Aug. 11. The Brewers are looking for Christian Yelich to return to form, as the 2018 NL MVP has hit just 21 home runs over the last two years after averaging 40 over the previous two campaigns. 

The model also knows Chicago ace Kyle Hendricks posted 14 victories last season but was winless over his final seven starts. The 32-year-old righty won just one of his four turns against the Brewers in 2021, allowing 15 runs and 28 hits over 22 innings. The Cubs are expecting big things from 27-year-old Japanese outfielder Seiya Suzuki, who signed a five-year, $85 million contract after hitting a career-high 38 homers and winning his second Central League batting title with a .317 average for the Hiroshima Toyo Carp last year.

Now, it has set its sights on Brewers vs. Cubs. We can tell you the model is leaning Over on the total, projecting 9.4 combined runs, and it also says one side of the money line has ALL the value! You ABSOLUTELY need to see it before locking in any MLB picks of your own.

So who wins Brewers vs. Cubs? And which side of the money line has ALL the value? ... Join SportsLine right now to find out which side of the Cubs vs. Brewers money line you should be all over on Thursday, all from the model that went 209-178 on top-rated MLB money-line picks in 2021!