Brewers vs. Cardinals odds, line, prediction: 2026 MLB picks for Wednesday, May 6, from proven model

The Milwaukee Brewers meet the St. Louis Cardinals in the final game of their rain-shortened two-game National League Central Division series on Wednesday afternoon. St. Louis earned a 6-3 win on Monday, before Tuesday's game was postponed by inclement weather. The Brewers (18-16), who have won three of five, are 8-8 on the road this season. The Cardinals (21-14), who have won seven of eight, are 10-9 on their home field in 2026. Milwaukee is without outfielder Christian Yelich (groin).

First pitch from Busch Stadium in St. Louis is set for 1:15 p.m. ET. The Cardinals lead the all-time series 259-209, and have won four of the last five meetings. Milwaukee is a -111 favorite on the money line (risk $111 to win $100) in the latest Brewers vs. Cardinals odds, while the over/under, is 8.5. Before making any Brewers vs. Cardinals picks, or MLB predictions, you NEED to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times, and is coming off a 5-0 week on top-rated MLB picks. It also excelled at making home run prop picks in 2025, returning nearly 30 units of profit. Anybody following its MLB betting picks at sportsbooks and on betting sites could have seen strong returns.   

The model has simulated Brewers vs. Cardinals 10,000 times and the results are in. The model is going Over on the total, and is also says one side of the money line has ALL the value!

Who wins Brewers vs. Cardinals, and which side of the money line has ALL the value? ... Join SportsLine right now to find out which side of the Brewers vs. Cardinals money line you should be all over, all from the model that went 5-0 on top-rated MLB picks last week!