The Seattle Mariners look to sweep their four-game wrap-around series with the Houston Astros when they meet in a key American League West Division matchup on Monday afternoon. Seattle is coming off a 6-1 win over Houston on Sunday. The Astros (6-10), who have lost seven in a row, are 1-8 on the road this season. The Mariners (7-9), who have won three in a row, are 6-4 on their home field in 2026.
First pitch from T-Mobile Park in Seattle is set for 4:10 p.m. ET. The Astros lead the all-time series 135-100, but the Mariners have won each of the last six meetings. Seattle is a -171 favorite on the money line (risk $171 to win $100) in the latest Astros vs. Mariners odds, while the over/under, is 7.5.