Head coach Deion Sanders and the Colorado Buffaloes (4-2, 2-1) hit the road looking to move one step closer to bowl eligibility when they take on the Wildcats (3-3, 1-2) on Saturday. Kickoff at Arizona Stadium is scheduled for 4 p.m. ET. The Buffs are coming off a 31-28 home loss to Kansas State. Shedeur Sanders threw for 388 yards and three touchdowns in the loss. Heisman Trophy candidate Travis Hunter suffered a shoulder injury and missed most of the second half against Kansas State, but is expected to play on Saturday. 

Arizona is looking to snap a two-game losing streak and bounce back from a 41-19 blowout loss to BYU. Junior wide receiver Tetairoa McMillan is an All-American candidate and projected first round pick for Arizona. CU is 4-2 and Arizona is 1-5 against the spread this season.

After opening at -4.5, the Wildcats are now 2.5-point favorites in the latest Arizona vs. Colorado odds via SportsLine consensus, while the over/under for total points scored is 58. Arizona is a -132 (risk $132 to win $100) favorite on the money line, with Colorado listed as a +110 underdog (see up-to-date odds for every game this week on our college football odds page). 

Before you make any Colorado vs. Arizona picks or any other college football predictions, you NEED to see which side proven SportsLine expert Jimmie Kaylor is on. 

Kaylor is a NFL, college football and DFS expert for SportsLine, who has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America. His background as a former college football All-American and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks. He has his finger on the pulse of the college football landscape and has been cashing in big for the last two years. 

Kaylor has destroyed the books in college football the last two seasons, netting a whopping 53.9 units while posting a 163-102-2 record since Week 1 of the 2023 season. Anyone who followed his picks finished the season WAY UP!

Now, Kaylor has locked in a confident against-the-spread pick for Colorado vs. Arizona in their Week 8 matchup in Tucson. We can tell you he's leaning Over on the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

Who wins Colorado vs. Arizona in their Week 8 matchup in Tucson on Saturday, and what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to see which side of the spread to jump on, all from the expert who is 163-102-2, returning $5,390 for $100 bettors, betting on college football since Week 1 of the 2023 season, and find out!

Be sure to follow Jimmie (@jimmiekaylor) on Twitter for notifications about picks changes/updates