Angels vs. Tigers odds, line, prediction: 2026 MLB picks for Thursday, May 28 from proven model

The Detroit Tigers host the Los Angeles Angels in the rubber match of a three-game interleague series on Thursday. The teams took turns winning; Los Angeles (21-35) won the opener 10-6 before Detroit (22-34) took Wednesday's game 4-0. Grayson Rodriguez (1-1, 10.61 ERA, 2.14 WHIP, nine strikeouts gets the ball for the Angels, while the Tigers go with Jack Flaherty (0-6, 5.94 ERA, 1.66 WHIP, 55 strikeouts) for a getaway matchup. 

First pitch from Comerica Park is set for 1:10 p.m. ET. Detroit is a -131 favorite on the money line (risk $131 to win $100) while Los Angeles is at +110 in the latest Angels vs. Tigers odds. The over/under for total runs is 8.5.

Before making any Angels vs. Tigers picks, or MLB predictions, you NEED to see what the SportsLine Projection Model has to say.

SportsLine Projection Model simulates every MLB game 10,000 times and enters Week 10 of the MLB season on a red-hot 14-4 run (78%) on all top-rated MLB picks. It also excelled at making home run prop picks in 2025, returning nearly 30 units of profit. Anybody following could have seen strong returns!

The model has simulated Angels vs. Tigers 10,000 times and the results are in. The model is going Over on the total, and is also says one side of the money line has ALL the value!

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