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The No. 13 Alabama Crimson Tide, who went 11-4 in 2025 after a Rose Bowl loss to eventual CFP champion Indiana, opens their 2026 season by hosting the East Carolina Pirates on Saturday at Bryant-Denny Stadium. Alabama named Keelon Russell as its starting quarterback after a competitive fall camp battle with Austin Mack, while ECU counters with sixth-year senior Mitch Griffis. Visit our DraftKings promo code review and get $200 in bonus bets as a new user after $5+ in wagers here:
Kickoff is set for noon ET at Bryant-Denny Stadium in Tuscaloosa, Ala. The Crimson Tide are 28-point favorites in the latest East Carolina vs. Alabama odds, while the over/under is 52.5.
Before making any Alabama vs. East Carolina picks, check out the college football predictions from the SportsLine Projection Model.
The model simulates every FBS game 10,000 times. It is on a 32-19 run on top-rated CFB money-line picks since the 2024 season, and it has been upgraded for the 2026 season to even better factor in the transfer portal!
The model has simulated Alabama vs. East Carolina 10,000 times and the results are in. The model is going Under on the total, and it also says one side of the spread hits well over 50% of the time!
So who wins Alabama vs. East Carolina, and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the Alabama vs. East Carolina spread you need to jump on, all from the computer model that is on a 32-19 run on top-rated CFB picks!
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