The Philadelphia 76ers and Boston Celtics square off in an intriguing division matchup at 7:30 p.m. ET on Wednesday. Boston is favored by 2.5 points at Caesars Sportsbook, while the Over-Under is set at 206 (see up-to-date odds for every game this week on our NBA odds page). Before making any 76ers vs. Celtics picks, you NEED to check out the NBA predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in profit on its top-rated NBA picks over the past three-plus seasons. The model enters Week 7 of the 2021-22 NBA season up over $1,500 on all top-rated NBA picks this season. It's also on a stunning 117-77 roll on top-rated NBA picks against the spread that dates back to last season. Anyone following it has seen HUGE returns.

The model knows the 76ers are a top-tier offense, scoring more than 1.1 points per possession this season. Philadelphia is an above-average shooting team, making 45.9 percent of all shots and 36.0 percent of three-point attempts, and the 76ers make real gains at the free throw line by converting 81.7 percent of attempts. The 76ers are also elite in ball security, committing only 12.6 turnovers per game. On defense, Philadelphia is above-average in steals (8.1 per game), blocks (5.9 per game) and free throw prevention, with Boston entering the night just No. 25 in the NBA in shooting efficiency.

The model also knows the Celtics excel defensively. Boston is allowing fewer than 1.05 points per possession, ranking in the top five of the NBA this season in overall defensive efficiency. Opponents are shooting just 43.5 percent against the Celtics in 2021-22, and the Celtics are allowing only 21.5 assists per game. Boston is tremendous on the defensive glass, securing 74.7 percent of rebounds and allowing only 11.4 second-chance points per game. The Celtics are also fantastic in protecting the paint, allowing 43.0 points per game in the lane and blocking 5.6 shots per contest.

Now, it has set its sights on 76ers vs. Celtics. We can tell you the model is leaning over the total, and it also says one side of the spread hits in well over 50 percent of simulations! You ABSOLUTELY need to see it before locking in any NBA picks.

Who wins 76ers vs. Celtics? And which side of the spread hits in well over 50 percent of simulations? ... Join SportsLine right now to find out which side of the 76ers vs. Celtics spread you should be all over Wednesday, all from the model on a roll on NBA picks!