A pair of NFC West contenders open their regular seasons when the San Francisco 49ers battle the Los Angeles Rams in a 2026 Week 1 matchup in Melbourne, Australia. Both teams tied for second in the division with 12-5 records last year. The Rams fell short to the eventual champion Seattle Seahawks 31-27 in the NFC Championship Game. The 49ers also were eliminated by the Seahawks, losing 41-6 in a divisional round matchup.
Kickoff is at 8:35 p.m. ET from Melbourne Cricket Ground. The latest 49ers vs. Rams odds have Los Angeles as 3.5-point favorites, while the over/under for total points scored is 48.5 via SportsLine consensus.
Before making any 49ers vs. Rams picks, or 2026 NFL Week 1 predictions of your own, you NEED to see which side the proven SportsLine projection model is on.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters the 2026 NFL season on a 53-37 run on top-rated picks dating back to 2024. Anybody following could have seen HUGE returns!
Now, the model has locked in another confident pick for 49ers vs. Rams on Thursday, Sept. 10.
We can tell you it's leaning Over the point total, but also says that one side of the spread hits well over 60% of the time! You ABSOLUTELY NEED to see which side to back before locking in any picks of your own.
So who wins Rams vs. 49ers in NFL Week 1, and which side of the spread hits in well over 60% of simulations? ... Join SportsLine RIGHT NOW to see which side of the 49ers vs. Rams line to back, all from the model that has gone 53-37 on top-rated picks since 2024!
LIMITED TIME: Use promo code CHAMPIONSHIP to get your first month at SportsLine for $1 JOIN NOW.
GET VEGAS EXPERT PICKS FOR NFL, MLB, NBA, CBB, GOLF, NHL, HORSE RACING AND MORE - PLUS ADVANCED COMPUTER SIMULATIONS, WINNING TOOLS, AND MORE!
Written by Daniel Kohn
View expert profile
