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NFC West rivals and Super Bowl contenders clash when the San Francisco 49ers battle the Los Angeles Rams in a season-opening matchup at Melbourne, Australia, on Thursday. Los Angeles and San Francisco tied for second in the division at 12-5 in 2025. The Rams are looking to reach their third Super Bowl in nine seasons, and first since winning Super Bowl LVI during the 2021 season. The 49ers, meanwhile, are looking to reach their third Super Bowl in eight seasons, and first since losing to Kansas City in Super Bowl LVIII during the 2023 season. Visit our DraftKings promo code review and get $200 in bonus bets as a new user after $5+ in wagers here:
Kickoff is at 8:35 p.m. ET from Melbourne Cricket Ground. The latest 49ers vs. Rams odds have Los Angeles as a 3.5-point favorite, while the over/under for total points scored is 48.5.
Before making any 49ers vs. Rams picks, or 2026 NFL Week 1 Australian game predictions of your own, you NEED to see what SportsLine expert Micah Roberts has to say.
Roberts has worked in the Las Vegas sportsbook industry for 20-plus years, including a 13-year run as Station Casinos' book director. Armed with an elaborate network of sources, Roberts switched to the other side of the counter and now hands out unique insights in multiple sports. He enters this season on a 19-5 roll on picks involving the 49ers, returning $1,350 to $100 players! Anyone following his picks could have seen huge returns.
Now, Roberts has locked in another confident pick for 49ers vs. Rams.
He's leaning Over the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.
So who wins 49ers vs. Rams on Thursday, and what x-factor makes one side of the spread hit HARD? ... Join SportsLine RIGHT NOW to see which side of the 49ers vs. Rams line to back, all from the expert who has returned $1,350 to $100 players in his last 24 picks involving the 49ers!
Don't miss out: All new SportsLine memberships include Paramount+ Premium -- a $13.99/month value -- for no extra cost! Join now and get it all.
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Written by Daniel Kohn
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