49ers vs. Patriots odds, line: 2024 NFL picks, Week 4 predictions from proven computer model

After two straight losses, the defending NFC champions, the San Francisco 49ers look to bounce back in Week 4 as they host the New England Patriots on Sunday. San Francisco (1-2) fell to the Rams, 27-24, while New England (1-2) lost to the Jets, 24-3 last Thursday night. The 49ers have won two of the last three meetings, including a 33-6 victory in Foxboro in October 2020.

Kickoff from Levi's Stadium is set for 4:05 p.m. ET. San Francisco is a 10.5-point favorite in the latest 49ers vs. Patriots odds, while the over/under for total points is 42. The 49ers are -595 money-line favorites (risk $595 to win $100). Before making any New England vs. San Francisco picks, you NEED to check out the NFL predictions from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 4 of the 2024 NFL season on an incredible 188-130 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 42-22 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP!

The model has simulated 49ers vs. Patriots 10,000 times and the results are in. We can tell you the model is leaning Under on the total. It also says one side of the spread hits over 50% of the time! You ABSOLUTELY need to see what it is before locking in any NFL picks of your own!

Who wins New England vs. San Francisco, and which side of the spread hits in over 50% of simulations? Join SportsLine right now to find out which side of the spread you should be all over, all from the model that is up well over $7,000 on its NFL picks!