The Week 7 NFL schedule features a Super Bowl LVIII rematch with the San Francisco 49ers set to host the Kansas City Chiefs at Levi's Stadium. San Francisco is 3-3 overall and 2-1 at home, while Kansas City is 5-0 overall and 2-0 on the road. The Chiefs are coming off a bye in Week 6, and defeated the New Orleans Saints 26-13 in their last game. The 49ers had an extended break as well after beating the Seattle Seahawks 36-24 on Thursday Night Football in Week 6.

Kickoff is at 4:25 p.m. ET. The 49ers are favored by 1.5 points in the latest 49ers vs. Chiefs odds from SportsLine consensus, and the over/under is 47 points. San Francisco is a -128 money-line favorite (risk $128 to win $100). Before locking in any 49ers vs. Chiefs picks, you'll want to see the NFL predictions and betting advice from the proven computer simulation model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 7 of the 2024 NFL season on an incredible 11-3 hot streak on top-rated NFL picks this year. Longer term, it is on a 192-132 roll on top-rated NFL picks that dates back to the 2017 season and a 46-24 roll on top-rated NFL picks since Week 7 of 2022. The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

The model has simulated 49ers vs. Chiefs 10,000 times and the results are in. We can tell you that the model is leaning Over on the point total, and it's also generated a point-spread pick that hits in over 50% of simulations. You can only see the model's pick at SportsLine.

So who wins 49ers vs. Chiefs? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks.